Horizon Pharma plc
May 8, 2017

Horizon Pharma plc Announces First-Quarter 2017 Results and Revises Full-Year 2017 Net Sales and Adjusted EBITDA Guidance

-- First-Quarter 2017 Net Sales of $220.9 Million; Up 8 Percent --

-- First-Quarter 2017 Net Loss of $90.6 Million; Adjusted EBITDA of $51.9 Million --

-- First-Quarter 2017 Net Sales from Rare Disease Medicines Increased 75 Percent and Represented 65 Percent of Total Company Net Sales --

-- Increased Investment in its Rapidly Growing Orphan Biologic Medicine for Refractory Chronic Gout, KRYSTEXXA® --

-- Raising KRYSTEXXA Peak Annual Net Sales Estimate to More than $400 Million from
More than $250 Million --

-- Announces Acquisition of River Vision Development Corp. and Teprotumumab, a Biologic in Late-Stage Development for a Rare Eye Disease --

-- Revising Full-Year 2017 Net Sales Guidance Range to $1.000 Billion to $1.035 Billion and Full-Year 2017 Adjusted EBITDA Guidance Range to $315 Million to $350 Million; Reflects Revisions to the Primary Care Business Unit Assumptions, Increased Investment in KRYSTEXXA and R&D Investment in Teprotumumab --

-- Announces Board of Directors' Authorization of Share Repurchase Program for Approximately
10 Percent of Shares Outstanding --

DUBLIN, Ireland, May 08, 2017 (GLOBE NEWSWIRE) -- Horizon Pharma plc (NASDAQ:HZNP), a biopharmaceutical company focused on improving patients' lives by identifying, developing, acquiring and commercializing differentiated and accessible medicines that address unmet medical needs, announced its first-quarter 2017 financial results today and revised its full-year 2017 net sales and adjusted EBITDA guidance. 

"We generated strong first-quarter performance in our orphan and rheumatology business units, with KRYSTEXXA and RAVICTI achieving record net sales; however, our primary care business unit performed well below our expectations," said Timothy P. Walbert, chairman, president and chief executive officer, Horizon Pharma plc.  "The lower primary care business unit results were related to the implementation of the contracting model with pharmacy benefit managers, which has not performed in accordance with our expectations.  While we are proactively addressing this underperformance, with greater visibility into the impact of this transition, we are revising our full-year 2017 net sales and adjusted EBITDA guidance."

Mr. Walbert added, "We have transformed Horizon Pharma into a company focused on rare disease medicines and we are significantly increasing our investment in one of our key growth drivers, KRYSTEXXA, which we now believe can exceed $400 million in peak annual sales.  That investment is supported by our continued expectation of strong cash-flow generation for the year, which also allows us to continue to seek attractive acquisitions, such as River Vision, which we announced today.  These actions, in addition to our newly authorized share repurchase program, reflect our confidence in the long-term value of our Company."      

Financial Highlights

       
(in millions except for per share amounts and percentages) Q1 17 Q1 16 %
Change
       
Net sales $  220.9  $  204.7    8 
Net loss    (90.6)    (45.4)   99 
Non-GAAP net income    35.0     41.3    (15)
Adjusted EBITDA    51.9     72.0    (28)
       
Net loss per share - diluted    (0.56)    (0.28)   100 
Non-GAAP earnings per share - diluted    0.21     0.25    (16)
       

Company Highlights

First-Quarter 2017 Business Unit Net Sales Results

           
  (in millions except for percentages)Q1 17 Q1 16 %
Change
  
  Orphan$   112.5  $   66.3  70    
    RAVICTI®   43.9    37.1 18   
    PROCYSBI®(1)    34.3    -  NM(2)   
    ACTIMMUNE®   26.2    25.5 3   
    BUPHENYL®    6.3    3.7 69   
    QUINSAIRTM(1)    1.8    -  NM   
  Rheumatology   42.8      27.4  56    
    KRYSTEXXA®(3)   31.6    16.2   96   
    RAYOS®   10.3    10.5 (2)  
    LODOTRA®   0.9    0.7 24   
  Primary Care   65.6     111.0  (41)  
    PENNSAID® 2%    41.6    55.0 (24)  
    DUEXIS®   17.7    29.6 (40)  
    VIMOVO®    4.9    25.5 (81)  
    MIGERGOT®(3)   1.4    0.9   57   
  Total net sales$   220.9  $   204.7  8    
           
  (1) PROCYSBI and QUINSAIR were acquired on October 25, 2016.  
  (2) Q1 16 pre-acquisition net sales of PROCYSBI were $27.5 million  
  (3) KRYSTEXXA and MIGERGOT were acquired on January 13, 2016.  
           

• Orphan Business Unit:  First-quarter orphan business unit net sales increased 70 percent compared to the first quarter of 2016.  

RAVICTI net sales in the first quarter of 2017 were $43.9 million, an increase of 18 percent compared to the first quarter of 2016.  The Company expects RAVICTI to be launched in Europe later in 2017 in partnership with Swedish Orphan Biovitrum AB (SOBI). 

PROCYSBI net sales in the first quarter of 2017 were $34.3 million, up 25 percent compared to Raptor's pre-acquisition net sales of $27.5 million in the first quarter of 2016, driven by continued strong patient demand from both patients converting from older-generation therapy as well as treatment-naïve patients.

ACTIMMUNE net sales in the first quarter of 2017 were $26.2 million, an increase of 3 percent versus the first quarter of 2016.  The Company has evolved its strategy to establish the role of ACTIMMUNE in a broader range of chronic granulomatous disease patients and ACTIMMUNE remains on track to return to growth for the full-year 2017.

The Company continues to make progress in the Phase 1 dose escalation trial evaluating ACTIMMUNE as part of a combination therapy in solid tumors for certain cancers.  In February, preliminary data presented at the American Society of Clinical Oncology Clinical Immuno-Oncology Symposium conference showed that combination therapy of ACTIMMUNE with nivolumab, a PD-1 inhibitor, was safe and well-tolerated in the first two cohorts.  The data also showed statistically significant activation of certain monocytes, or white blood cells in peripheral blood, which demonstrates that ACTIMMUNE is having the desired effect of stimulating immune cells.  These are early results, and the third cohort of patients is still under study.  In the first quarter of 2017, a fourth cohort was added to the study to more fully assess dose response.  In addition, a number of academic and clinical institutions have expressed interest in studying ACTIMMUNE as combination therapy in certain cancers, including the National Cancer Institute, which plans to initiate a study later this year to treat patients with Cutaneous T-Cell Lymphoma (CTCL) with ACTIMMUNE and pembrolizumab, a PD-1 inhibitor.  

The acquisition of River Vision provides the Company with teprotumumab, a fully human monoclonal antibody that targets Insulin-like Growth Factor-1 receptor (IGF-1R).  Teprotumumab is in late-stage development for TED, and has received Orphan Drug, Fast Track and Breakthrough Therapy designations from the FDA.  On May 4, 2017, The New England Journal of Medicine published teprotumumab Phase 2 study results that demonstrate significant clinical efficacy in TED.  Teprotumumab was also safe and well tolerated.  The Company expects to begin a Phase 3 pivotal program of teprotumumab in TED in the second half of 2017.

• Rheumatology Business Unit:  KRYSTEXXA net sales in the first quarter of 2017 were $31.6 million, an increase of 96 percent compared to the first quarter of 2016.  Since acquiring the medicine in January of 2016, the Company's improved commercial strategy and additional investment in commercial, education and outreach efforts has rapidly accelerated KRYSTEXXA net sales.

Based on the continued increase in uptake of KRYSTEXXA and the clear unmet need that exists for thousands of refractory chronic gout sufferers, the Company will significantly increase its infrastructure and investment in the medicine.  Beginning in the second quarter and continuing through the second half of 2017, the Company will expand its commercial organization to nearly 200 employees from more than 100.  With the additional resources, the Company expects to expand its reach to physicians and increase awareness of refractory chronic gout among physicians and patients.  As a result, the Company now expects KRYSTEXXA annual peak net sales of more than $400 million versus the previous estimate of more than $250 million.

• Primary Care Business Unit:  Total net sales for the primary care business unit were $65.6 million in the first quarter of 2017.  Net sales of PENNSAID 2%, DUEXIS and VIMOVO in the first quarter of 2017 were $41.6 million, $17.7 million and $4.9 million, respectively. 

During the second half of 2016, the Company entered into rebate agreements with pharmacy benefit managers (PBMs) in an effort to secure broader inclusion of its primary care medicines on healthcare plan formularies.  This transition to PBM rebate agreements, most of which became effective January 1, 2017, was a change to the commercial model of the Company's primary care business unit, and following this transition, first-quarter 2017 primary care business unit net sales were lower than the Company's expectations. 

Total prescription volumes for DUEXIS, VIMOVO and PENNSAID 2% were approximately in line with the Company's expectations in the first quarter of 2017.  However, the average net realized price (ANRP) was significantly below expectations due to higher patient assistance costs and higher PBM rebate levels than anticipated.  This was a function of lower-than-anticipated adoption rates of the Company's primary care medicines onto certain healthcare plan formularies (custom clients), resulting in higher patient assistance costs to the Company, as well as fact that PBM plans that covered the Company's primary care medicines are primarily plans that require a higher rebate (PBM-chosen formulary clients), resulting in higher rebate costs.  To a lesser extent, the lower ANRP in the quarter was also due to a higher rate of managed care control in the Company's non-contracted business, reflecting an industry-wide trend.

PBM clients broadly fall into two categories, clients that follow a PBM-chosen formulary and clients where the PBM works on their behalf to provide customized formularies (custom clients).  Rebate amounts paid to the PBMs for custom clients are typically lower than rebate amounts paid to the PBM for PBM-chosen formulary clients. 

When the Company established its financial guidance for full-year 2017, the Company estimated the adoption trajectory and mix of PBM clients that the change to its commercial model would generate.  This took into account input from the PBMs.  The Company did not have full visibility into the actual PBM client mix and the magnitude of the difference compared to its assumptions until it received detailed PBM invoices in late April and early May. 

While the Company continues to work to drive adoption of its medicines with custom clients, it now expects a much lower level of adoption of custom client plans in 2017.  Compared to its previous financial guidance, the Company has incorporated a higher level of rebates, a higher level of patient assistance costs and a lower level of total prescription volume into its full-year 2017 primary care business unit net sales forecast.  It is also reducing certain primary care business unit operating costs as well as other company costs to align its cost structure with revised net sales expectations.  As a result, the Company has lowered its full-year 2017 net sales and adjusted EBITDA guidance.

First-Quarter 2017 Financial Results
Note:  For additional detail and reconciliation of non-GAAP financial measures to the most directly comparable GAAP financial measures, please refer to the tables at the end of this release.

Cash Flow Statement and Balance Sheet Highlights

Full-Year 2017 Guidance

For the full-year 2017, the Company expects continued strong net sales growth for both its orphan and rheumatology businesses, driven primarily by strong patient growth in KRYSTEXXA, RAVICTI and PROCYSBI.  In its primary care business unit, the Company is assuming net sales of more than $300 million.

As a result of these expectations, the Company revised its full-year 2017 net sales guidance range to $1.000 billion to $1.035 billion from $1.240 billion to $1.290 billion.  The Company revised its full-year 2017 adjusted EBITDA guidance to $315 million to $350 million from $525 million to $575 million, which assumes the lower net sales range and accounts for cost reductions, primarily in its primary care business, and a reinvestment of a portion of these reductions in KRYSTEXXA to maximize its long-term potential.  It also reflects an approximate $20 million increase in operating expenses, primarily in R&D, for full-year 2017 related to teprotumumab.  The Company is raising its estimate of peak annual net sales for KRYSTEXXA to $400 million from $250 million. 

Conference Call

At 7:30 a.m. EST / 12:30 p.m. IST today, the Company will host a live conference call and webcast to review its financial and operating results and provide a general business update.

U.S. Dial-In Number: +1 888.338.8373
International Dial-In Number:  +1 973.872.3000
Passcode:  4624726

The live webcast and a replay may be accessed by visiting Horizon's website at http://ir.horizon-pharma.com.  Please connect to the Company's website at least 15 minutes prior to the live webcast to ensure adequate time for any software download that may be needed to access the webcast.

A replay of the conference call will be available approximately two hours after the call and accessible through one of the following telephone numbers, using the passcode below:

Replay U.S. Dial-In Number:  +1 855.859.2056
Replay International Dial-In Number:  +1 404.537.3406
Passcode:  4624726

About Horizon Pharma plc
Horizon Pharma plc is a biopharmaceutical company focused on improving patients' lives by identifying, developing, acquiring and commercializing differentiated and accessible medicines that address unmet medical needs.  The Company markets 11 medicines through its orphan, rheumatology and primary care business units.  For more information, please visit www.horizonpharma.com.  Follow @HZNPplc on Twitter or view careers on our LinkedIn page.

Note Regarding Use of Non-GAAP Financial Measures
EBITDA, or earnings before interest, taxes, depreciation and amortization, and adjusted EBITDA are used and provided by Horizon Pharma as non-GAAP financial measures.  Horizon Pharma provides certain other financial measures such as non-GAAP net income, non-GAAP diluted earnings per share, non-GAAP gross profit and gross profit ratio, non-GAAP operating expenses, non-GAAP tax rate and non-GAAP operating cash flow, each of which include adjustments to GAAP figures.  These non-GAAP measures are intended to provide additional information on Horizon Pharma's performance, operations, expenses, profitability and cash flows.  Adjustments to Horizon Pharma's GAAP figures as well as EBITDA exclude acquisition-related expenses, charges related to the discontinuation of ACTIMMUNE development for Friedreich's ataxia, an upfront fee for a license of a patent, a litigation settlement, loss on debt extinguishment and loss on sale of long-term investments, costs of debt refinancing, drug manufacturing harmonization costs, as well as non-cash items such as share-based compensation, depreciation and amortization, royalty accretion, non-cash interest expense, intangible and other non-current asset impairment charges, and other non-cash adjustments.  Certain other special items or substantive events may also be included in the non-GAAP adjustments periodically when their magnitude is significant within the periods incurred.  Horizon maintains an established non-GAAP cost policy that guides the determination of what costs will be excluded in non-GAAP measures.  Horizon Pharma believes that these non-GAAP financial measures, when considered together with the GAAP figures, can enhance an overall understanding of Horizon Pharma's financial and operating performance.  The non-GAAP financial measures are included with the intent of providing investors with a more complete understanding of the Company's historical and expected 2017 financial results and trends and to facilitate comparisons between periods and with respect to projected information.  In addition, these non-GAAP financial measures are among the indicators Horizon Pharma's management uses for planning and forecasting purposes and measuring the Company's performance.  For example, adjusted EBITDA is used by Horizon Pharma as one measure of management performance under certain incentive compensation arrangements.  These non-GAAP financial measures should be considered in addition to, and not as a substitute for, or superior to, financial measures calculated in accordance with GAAP.  The non-GAAP financial measures used by the Company may be calculated differently from, and therefore may not be comparable to, non-GAAP financial measures used by other companies.  Horizon Pharma has not provided a reconciliation of its full-year 2017 adjusted EBITDA outlook to an expected net income (loss) outlook because certain items such as acquisition-related expenses and share-based compensation that are a component of net income (loss) cannot be reasonably projected due to the significant impact of changes in Horizon Pharma's stock price, the variability associated with the size or timing of acquisitions and other factors.  These components of net income (loss) could significantly impact Horizon Pharma's actual net income (loss).    

Forward-Looking Statements
This press release contains forward-looking statements, including, but not limited to, statements related to Horizon Pharma's full-year 2017 net sales and adjusted EBITDA guidance, expected peak annual sales of KRYSEXXA, growth of 2017 ACTIMMUNE net sales and 2017 nets sales of Horizon Pharma's primary care business unit medicines, expected financial performance in future periods, expected timing of clinical, regulatory and commercial events, including the planned Phase 3 pivotal clinical trial of teprotumumab and anticipated additional clinical trials of ACTIMMUNE in cancer indications, the timing and potential benefits of Horizon Pharma's acquisition of River Vision, planned reductions in the Company's primary care operating expenses and increases in R&D investment and KRYSTEXXA commercialization spending, the expected future impact of Horizon Pharma's primary care business unit PBM contracting commercial model, the expected launch of RAVICTI in Europe, potential market opportunity for Horizon Pharma's medicines in approved and potential additional indications, potential growth of Horizon Pharma's medicines and business and other statements that are not historical facts.  These forward-looking statements are based on Horizon Pharma's current expectations and inherently involve significant risks and uncertainties.  Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, risks that Horizon Pharma's actual future financial and operating results may differ from its expectations or goals; Horizon Pharma's ability to grow net sales from existing products; the availability of coverage and adequate reimbursement and pricing from government and third-party payers and risks relating to Horizon Pharma's ability to successfully implement its business strategies; whether Horizon Pharma is able to realize expected benefits from arrangements with PBMs; risks related to acquisition integration and achieving projected benefits; risks associated with clinical development and regulatory approvals; risks in the ability to recruit, train and retain qualified personnel; competition, including potential generic competition; the ability to protect intellectual property and defend patents; regulatory obligations and oversight, including any changes in the legal and regulatory environment in which Horizon Pharma operates and those risks detailed from time-to-time under the caption "Risk Factors" and elsewhere in Horizon Pharma's filings and reports with the SEC.  Horizon Pharma undertakes no duty or obligation to update any forward-looking statements contained in this presentation as a result of new information.

Horizon Pharma plc 
Condensed Consolidated Statements of Operations (Unaudited) 
(in thousands, except share and per share data) 
      
  Three Months Ended March 31,  
   2017   2016  
       
Net sales $  220,859  $  204,690  
Cost of goods sold    139,116     77,233  
Gross profit    81,743     127,457  
      
OPERATING EXPENSES:     
Research and development    13,061     12,722  
Selling, general and administrative   174,065     141,939  
Total operating expenses    187,126     154,661  
Operating loss    (105,383)    (27,204) 
      
OTHER EXPENSE, NET:     
Interest expense, net    (31,983)     (19,458) 
Foreign exchange loss    (259)    (173) 
Loss on debt extinguishment    (533)    -   
Other income (expense), net    35      (14) 
Total other expense, net    (32,740)    (19,645) 
      
Loss before benefit for income taxes    (138,123)    (46,849) 
BENEFIT FOR INCOME TAXES    (47,553)    (1,443) 
NET LOSS $  (90,570) $  (45,406) 
      
Net loss per ordinary share - basic and diluted $  (0.56) $  (0.28) 
      
Weighted average ordinary shares outstanding - basic and diluted   161,972,052     159,904,416  
      


Horizon Pharma plc   
Condensed Consolidated Balance Sheets (Unaudited)    
(in thousands, except share data)   
        
        
  As of   
  March 31,
2017
 December 31,
2016
   
ASSETS     
CURRENT ASSETS:       
Cash and cash equivalents $   603,358  $  509,055    
Restricted cash    6,989     7,095    
Accounts receivable, net    396,785     305,725    
Inventories, net    137,839     174,788    
Prepaid expenses and other current assets    52,091     49,619    
Total current assets    1,197,062     1,046,282    
Property and equipment, net    23,557     23,484    
Developed technology, net    2,697,710     2,767,184    
Other intangible assets, net    6,048     6,251    
Goodwill    445,579     445,579    
Deferred tax assets, net    1,957     911    
Other assets    2,843     2,368    
TOTAL ASSETS $  4,374,756  $  4,292,059    
        
LIABILITIES AND SHAREHOLDERS' EQUITY       
CURRENT LIABILITIES:        
Long-term debt—current portion $  8,500  $  7,750    
Accounts payable    87,739     52,479    
Accrued expenses    144,846     182,765    
Accrued trade discounts and rebates    413,643      297,556    
Accrued royalties—current portion    60,307     61,981    
Deferred revenues—current portion    2,935     3,321    
Total current liabilities    717,970     605,852     
        
LONG-TERM LIABILITIES:       
Exchangeable notes, net    301,942     298,002     
Long-term debt, net, net of current    1,578,820     1,501,741    
Accrued royalties, net of current    273,191     272,293    
Deferred revenues, net of current    7,639     7,763    
Deferred tax liabilities, net    242,708     296,568    
Other long-term liabilities    46,808     46,061    
Total long-term liabilities    2,451,108     2,422,428    
        
COMMITMENTS AND CONTINGENCIES       
SHAREHOLDERS' EQUITY:       
Ordinary shares, $0.0001 nominal value; 300,000,000 shares authorized;        
163,008,960 and 162,004,956 issued at March 31, 2017 and December 31, 2016,       
respectively, and 162,624,594 and 161,620,590 outstanding at March 31, 2017 and        
December 31, 2016, respectively    16     16    
Treasury stock, 384,366 ordinary shares at March 31, 2017 and December 31, 2016    (4,585)    (4,585)   
Additional paid-in capital    2,144,385     2,119,455    
Accumulated other comprehensive loss    (2,758 )    (3,086)   
Accumulated deficit    (931,380)    (848,021)   
Total shareholders' equity    1,205,678     1,263,779    
TOTAL LIABILITIES AND SHAREHOLDERS' EQUITY $  4,374,756  $  4,292,059    
        


Horizon Pharma plc
Condensed Consolidated Statements of Cash Flows (Unaudited)
(in thousands)
     
   
  Three Months Ended March 31, 
   2017   2016 
   
CASH FLOWS FROM OPERATING ACTIVITIES:    
Net loss $  (90,570) $  (45,406)
Adjustments to reconcile net loss to net cash provided by operating activities     
Depreciation and amortization expense    71,483     50,642 
Equity-settled share-based compensation    28,837     27,745  
Royalty accretion    12,959     9,359 
Royalty liability remeasurement    (2,944)    -  
Loss on debt extinguishment    388     -  
Payments related to term loan refinancing    (3,940)    -  
Amortization of debt discount and deferred financing costs    5,423     4,425 
Deferred income taxes    (47,695)    (2,657)
Foreign exchange and other adjustments    787     173 
Changes in operating assets and liabilities:    
Accounts receivable    (91,058)    (69,838)
Inventories    37,050     7,317 
Prepaid expenses and other current assets    (2,445)    (242)
Accounts payable     36,078     52,856 
Accrued trade discounts and rebates    116,079     40,601 
Accrued expenses and accrued royalties    (49,359)    (23,521)
Deferred revenues    (618)    (498)
Other non-current assets and liabilities    266     3,225 
Net cash provided by operating activities    20,721     54,181 
CASH FLOWS FROM INVESTING ACTIVITIES:    
Payments for acquisitions, net of cash acquired    -      (514,814)
Change in restricted cash    104     (918)
Purchases of property and equipment    (1,421)    (7,525)
Net cash used in investing activities    (1,317)    (523,257)
CASH FLOWS FROM FINANCING ACTIVITIES:    
Net proceeds from term loans    847,768     -  
Repayment of term loans    (768,665)    (1,000)
Refunds related to the ESPP plan    (173)    -  
Proceeds from the issuance of ordinary shares in connection with stock option exercises   544     919 
Payment of employee withholding taxes related to share-based awards   (4,277)    (4,185)
Net cash provided by (used in) financing activities    75,197     (4,266)
     
Effect of foreign exchange rate changes on cash and cash equivalents   (298)    (421)
     
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS   94,303     (473,763)
CASH AND CASH EQUIVALENTS, beginning of the period    509,055     859,616 
CASH AND CASH EQUIVALENTS, end of the period $   603,358   $   385,853  
     


Horizon Pharma plc 
Presentation of Selling, General and Administrative Expenses (Unaudited) 
(in thousands) 
          
   Q1 16Q2 16Q3 16Q4 16 FY 16 
          
Previous presentation:Sales and marketing $  75,544$  79,589$  72,564$  92,669 $  320,366 
 General and administrative    66,395   53,986   59,485   108,076    287,942 
Current presentation:Selling, general and administrative $  141,939$  133,575$  132,049$  200,745 $  608,308 
          
    Q1 15Q2 15Q3 15Q4 15 FY 15 
           
Previous presentation:Sales and marketing $  47,063$  58,056$  51,973$  63,352 $  220,444 
 General and administrative    26,280   77,190   54,516   61,875    219,861 
Current presentation:Selling, general and administrative $  73,343$  135,246$  106,489$  125,227 $  440,305 
          


Horizon Pharma plc
GAAP to Non-GAAP Reconciliations
Net Income and Earnings Per Share (Unaudited)
(in thousands, except share and per share data)
    
    
 Three Months Ended March 31, 
  2017    2016 
  
    
GAAP net loss$   (90,570) $   (45,406)
Non-GAAP adjustments:   
Remeasurement of royalties for medicines acquired through business combinations   (2,944)    -  
Acquisition-related costs   10,039     11,016 
Upfront fee for license of global patent   -      2,000 
Loss on debt extinguishment    533     -  
Fees related to term loan refinancing   4,143     -  
Amortization, accretion and step-up:   
Intangible amortization expense   69,677      49,650 
Amortization of debt discount and deferred financing costs   5,423     4,425 
Accretion of royalty liabilities   12,959     9,359 
Inventory step-up expense   40,595     7,446 
Share-based compensation   28,469     27,612 
Depreciation expense   1,806     992 
Drug substance harmonization costs   4,299     -  
Royalties for medicines acquired through business combinations   (11,317)    (8,500)
Total of pre-tax non-GAAP adjustments   163,682     104,000 
Income tax effect of pre-tax non-GAAP adjustments   (38,103)    (17,274)
Total of non-GAAP adjustments   125,579     86,726 
Non-GAAP Net Income$   35,009   $    41,320  
    
    
Non-GAAP Earnings Per Share:   
    
Weighted average shares - Basic    161,972,052      159,904,416  
    
Non-GAAP Earnings Per Share - Basic:   
GAAP loss per share - Basic    (0.56)    (0.28)
Non-GAAP adjustments    0.78     0.54 
Non-GAAP earnings per share - Basic   0.22      0.26  
    
    
Weighted average shares - Diluted   
Weighted average shares - Basic    161,972,052     159,904,416 
Ordinary share equivalents   2,895,016     3,756,579 
Weighted average shares - Diluted   164,867,068      163,660,995  
    
    
Non-GAAP Earnings Per Share - Diluted   
GAAP loss per share - Diluted    (0.56)    (0.28)
Non-GAAP adjustments   0.78     0.54 
Diluted earnings per share effect of ordinary share equivalents   (0.01)    (0.01)
Non-GAAP earnings per share - Diluted   0.21      0.25  
    


Horizon Pharma plc  
GAAP to Non-GAAP Reconciliations  
EBITDA, Gross Profit and Operating Cash Flow (Unaudited)  
(in thousands, except percentages)  
      
      
 Three Months Ended March 31,   
  2017   2016   
    
EBITDA and Adjusted EBITDA:     
      
GAAP net loss$   (90,570) $   (45,406)  
Depreciation   1,806     992   
Amortization, accretion and step-up:     
Intangible amortization expense    69,677     49,650   
Accretion of royalty liabilities   12,959     9,359   
Amortization of deferred revenue   (204)    (206)  
Inventory step-up expense   40,595     7,446   
Interest expense, net (including amortization of     
debt discount and deferred financing costs)    31,983     19,458   
Benefit for income taxes   (47,553)    (1,443)  
EBITDA$   18,693   $   39,850    
Non-GAAP adjustments:     
Remeasurement of royalties for medicines acquired through business combinations   (2,944)    -    
Acquisition-related costs   10,039     11,016   
Upfront fee for license of global patent   -      2,000   
Loss on debt extinguishment    533     -    
Fees related to term loan refinancing   4,143     -     
Share-based compensation   28,469     27,612   
Drug substance harmonization costs   4,299     -    
Royalties for medicines acquired through business combinations   (11,317)    (8,500)  
Total of Non-GAAP adjustments   33,222     32,128   
Adjusted EBITDA$   51,915   $   71,978    
      
      
Non-GAAP Gross Profit:     
      
GAAP gross profit$   81,743   $   127,457    
Non-GAAP gross profit adjustments:     
Acquisition-related costs   80     115   
Share-based compensation   428     -    
Remeasurement of royalties for medicines acquired through business combinations   (2,944)    -    
Intangible amortization expense (COGS only)   69,474     49,447   
Accretion of royalty liabilities   12,959     9,359   
Inventory step-up expense   40,595     7,446   
Depreciation (COGS only)   183     120   
Drug substance harmonization costs   4,299     -    
Royalties for medicines acquired through business combinations   (11,317)    (8,500)  
Total of Non-GAAP adjustments   113,757     57,987   
Non-GAAP gross profit $   195,500   $   185,444    
       
GAAP gross profit % 37.0%  62.3%  
Non-GAAP gross profit % 88.5%  90.6%  
      
Non-GAAP operating cash flow:     
      
GAAP cash provided by operating activities$   20,721   $   54,181    
Cash payments for acquisition-related costs   20,392     11,694   
Cash payment for litigation settlement   16,250     -    
Cash payments for upfront fee for license of global patent   -      2,000   
Cash payments for clinical trial wind-down costs   482     -    
Cash payment for debt extinguishment   145     -    
Cash payments relating to term loan refinancing   7,252     -    
Non-GAAP operating cash flow$   65,242    $   67,875    
      


Horizon Pharma plc 
GAAP to Non-GAAP Tax Rate Reconciliation (Unaudited) 
(in millions, except percentages) 
       
       
 Q1 17 
 Pre-tax Net
(Loss) Income
 Income Tax
(Benefit) Expense
 
Tax RateNet (Loss)
Income
Diluted (Loss)
Earnings Per Share
 
As reported - GAAP$  (138.1)$  (47.6)34.4%$  (90.6) $  (0.56) 
Non-GAAP adjustments   163.7    38.1     125.7   
Non-GAAP$  25.6 $  (9.4)-37.0%$  35.0 $  0.21   
       
       
 Q1 16 
 Pre-tax Net
(Loss) Income
 Income Tax
(Benefit) Expense
 
Tax RateNet (Loss)
Income
Diluted (Loss)
Earnings Per Share
 
As reported - GAAP$  (46.8)$  (1.4)3.1%$  (45.4)$  (0.28) 
Non-GAAP adjustments   104.0    17.3     86.7   
Non-GAAP$  57.2  $  15.9 27.7%$  41.3 $  0.25  
       

Horizon Pharma plc
Certain Income Statement Line Items - Non-GAAP Adjusted
For the Three Months Ended March 31, 2017
(Unaudited)

         
          
      Income Tax  
  Research &Selling, GeneralInterestLoss on DebtBenefit  
 COGSDevelopment& AdministrativeExpenseExtinguishment(Expense)  
         
GAAP as reported$  (139,116)$  (13,061)$  (174,065)$  (31,983)$  (533)$  47,553   
         
Non-GAAP Adjustments (in thousands):        
Acquisition-related costs(1) 80  177  9,782  -  -  -   
Loss on debt extinguishment(2) -  -  -  -  533  -   
Fees related to term loan refinancing(3) -  -  4,143  -  -  -   
Amortization, accretion and step-up:        
Intangible amortization expense(4) 69,474  -  203   -  -  -   
Amortization of debt discount and deferred financing costs(5) -  -   -  5,423  -  -   
Accretion of royalty liability(6) 12,959   -  -  -  -  -   
Inventory step-up expense(7) 40,595  -  -  -   -  -   
Remeasurement of royalties for products acquired through business combinations(8) (2,944) -  -  -  -  -   
Share-based compensation (9) 428  2,049  25,992  -  -  -    
Depreciation expense(10) 183  -  1,623  -  -   -   
Drug substance harmonization costs(11) 4,299  -       
Royalties for medicines acquired through business combinations(12) (11,317) -  -  -  -  -   
Income tax effect on pre-tax non-GAAP adjustments(13) -  -  -  -  -  (38,103)  
Total of non-GAAP adjustments 113,757  2,226  41,743  5,423  533  (38,103)  
         
Non-GAAP$(25,359)$(10,835)$(132,322)$(26,560)$- $9,450   
         
 Horizon Pharma plc 
 Certain Income Statement Line Items - Non-GAAP Adjusted 
 For the Three Months Ended March 31, 2016   
 (Unaudited) 
         
         
     Income Tax   
  Research &Selling, GeneralInterestBenefit   
 COGSDevelopment& AdministrativeExpense(Expense)   
         
GAAP as reported$(77,233)$(12,722)$(141,939)$(19,458)$1,443    
         
Non-GAAP Adjustments (in thousands):        
Acquisition-related costs(1) 115  32  10,869  -  -    
Upfront fee for license of global patent(14) -  2,000  -  -  -    
Amortization, accretion and step-up:        
Intangible amortization expense(4) 49,447  -  203  -  -    
Amortization of debt discount and deferred financing costs(5) -  -  -  4,425  -     
Accretion of royalty liability(6) 9,359  -  -   -  -    
Inventory step-up expense(7) 7,446  -  -   -  -    
Share-based compensation(9) -  2,125  25,487  -  -    
Depreciation expense(10) 120  -  872  -  -    
Royalties for medicines acquired through business combinations(12) (8,500) -  -   -  -    
Income tax effect on pre-tax non-GAAP adjustments(13) -  -  -  -  (17,274)   
Total of non-GAAP adjustments  57,987  4,157  37,431  4,425  (17,274)   
         
Non-GAAP$  (19,246)$  (8,565)$  (104,508)$  (15,033)$  (15,831)   
         

                        

  1. Expenses, including legal and consulting fees, incurred in connection with the Company's acquisitions of Raptor Pharmaceutical Corp. ("Raptor") , Crealta Holdings LLC ("Crealta"), Hyperion Therapeutics, Inc. ("Hyperion"), Vidara Therapeutics International Public Limited Company ("Vidara"), its agreement to acquire the worldwide rights to interferon gamma-1b and its withdrawn offer to acquire Depomed Inc. have been excluded.
     
  2. During the three months ended March 31, 2017, the Company recorded a loss on debt extinguishment of $533, which was comprised of the write-off of $388 in debt discount and deferred financing costs, and an early redemption payment of $145.
     
  3. During the three months ended March 31, 2017, the Company expensed $4,143 of arrangement and other fees relating to the refinancing of its term loans.
     
  4. Intangible amortization expenses are associated with the Company's intellectual property rights, developed technology and customer relationships of ACTIMMUNE, BUPHENYL, KRYSTEXXA, LODOTRA, MIGERGOT, PENNSAID 2%, PROCYSBI, RAVICTI, RAYOS and VIMOVO.
     
  5. Represents amortization of debt discount and deferred financing costs associated with the Company's debt.
     
  6. Represents accretion expense associated with the ACTIMMUNE, BUPHENYL, KRYSTEXXA, MIGERGOT, PROCYSBI, RAVICTI and VIMOVO royalties for the three months ended March 31, 2017 and represents accretion expense associated with the ACTIMMUNE, BUPHENYL, KRYSTEXXA, MIGERGOT, RAVICTI and VIMOVO royalties for the three months ended March 31, 2016.
     
  7. In connection with the Crealta acquisition, the KRYSTEXXA and MIGERGOT inventory was stepped up in value by $144,289 and during the three months ended March 31, 2017, the Company recognized in cost of goods sold, $14,357 for step-up inventory expenses related to KRYSTEXXA and MIGERGOT inventory sold.  During the three months ended March 31, 2016, the Company recognized in cost of goods sold, $7,446 for step-up inventory expenses related to KRYSTEXXA and MIGERGOT inventory sold.

    In connection with the Raptor acquisition, the PROCYSBI and QUINSAIR inventory was stepped up in value by $66,950 and during the three months ended March 31, 2017, the Company recognized in cost of goods sold $26,238 of step-up inventory expenses related to PROCYSBI and QUINSAIR inventory sold. 

  1. At the time of the Company's acquisition of the rights to ACTIMMUNE, BUPHENYL, KRYSTEXXA, MIGERGOT, PROCYSBI, RAVICTI and VIMOVO, the Company estimated the fair value of contingent royalties payable to third parties using an income approach under the discounted cash flow method, which included revenue projections and other assumptions the Company made to determine the fair value.  If the Company significantly overperforms or underperforms against its original revenue projections or it becomes necessary to make changes to assumptions as a result of a triggering event, the Company is required to reassess the fair value of the contingent royalties payable.  Any subsequent adjustment to fair value is recorded in the period such adjustment is made as either an increase or decrease to royalties payable, with a corresponding increase or decrease in cost of goods sold, in accordance with established accounting policies.  During the three months ended March 31, 2017, the Company recorded a net reduction of $2,944, to cost of goods sold to adjust the amount of the contingent royalty liabilities relating to VIMOVO and KRYSTEXXA.
     
  2. Represents share-based compensation expense associated with the Company's stock option, restricted stock unit, and performance stock unit grants to its employees and non-employees, its cash-settled long-term incentive program and its employee stock purchase plan.
     
  3. Represents depreciation expense related to the Company's property, equipment, software and leasehold improvements.
     
  4. During the year ended December 31, 2016, the Company committed to spend $14,900 related to the harmonization of the manufacturing processes for ACTIMMUNE and IMUKIN drug substance. During the three months ended March 31, 2017, the Company incurred $5,774 of this spend, including costs of $4,299 that qualify for exclusion in the Company's non-GAAP financial measures under the Company's non-GAAP cost policy.
     
  5. Royalties of $11,317 were incurred during the three months ended March 31, 2017, based on the periods' net sales for ACTIMMUNE, BUPHENYL, KRYSTEXXA, MIGERGOT, PROCYSBI, RAVICTI and VIMOVO.  Royalties of $8,500 were incurred during the three months ended March 31, 2016, based on the period's net sales for ACTIMMUNE, BUPHENYL, KRYSTEXXA, MIGERGOT, RAVICTI and VIMOVO.
     
  6. Income tax adjustments on pre-tax non-GAAP adjustments represent the estimated income tax impact of each pre-tax non-GAAP adjustment based on the statutory income tax rate of the applicable jurisdictions for each non-GAAP adjustment.
     
  7. Represents an upfront fee paid for a license of a global patent.
Contacts:



Investors:

Tina Ventura

Senior Vice President,

Investor Relations

investor-relations@horizonpharma.com



Ruth Venning

Executive Director,

Investor Relations

investor-relations@horizonpharma.com



U.S. Media:

Geoff Curtis

Senior Vice President,

Corporate Affairs & Chief Communications Officer

media@horizonpharma.com



Ireland Media:

Ray Gordon

Gordon MRM

ray@gordonmrm.ie

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Source: Horizon Pharma plc

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